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Motor neuron diseases are a group of conditions that cause the nerves in the spine and brain to lose function over time. They are a rare but severe form of neurodegenerative disease.Motor neurons are nerve cells that send electrical output signals to the muscles, affecting the muscles’ ability to function.Motor neuron disease (MND) can appear at any age, but symptoms usually appear after the age of. It affects more men than women.The most common type of MND, (ALS), probably affects up to Americans at any given time, with over 5,600 diagnoses each year, according to the ALS Association.The renowned English physicist Stephen Hawking lived with ALS for many decades until his death in March 2018.
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Guitar virtuoso Jason Becker is another example of someone who has been living with ALS for several years. Stephen Hawking was one of the most well-known people with MND.Image credit: Doug Wheller, 2008There are several of MND. Doctors classify them according to whether they are hereditary or not, and which neurons they affect.ALS, or Lou Gehrig’s disease, is the most common type, affecting both the upper and lower motor neurons (neurons in the brain and spinal cord). It affects the muscles of the arms, legs, mouth, and respiratory system. A person with ALS will live, on average, another, but, with supportive care, some people live 10 years or more.Primary lateral sclerosis affects the neurons in the brain. It is a of MND that advances more slowly than ALS.
It is not fatal, but it can affect a person’s quality of life. Juvenile primary lateral sclerosis can affect children.Progressive bulbar palsy (PBP) involves the brain stem.
People with ALS often have PBP too. The condition causes frequent choking spells, difficulty speaking, eating, and swallowing.Progressive muscular atrophy (PMA) is a rare condition that affects the lower motor neurons in the spinal cord.
It causes slow but progressive muscle wasting, especially in the arms, legs, and mouth.Spinal muscular atrophy (SMA) is an inherited MND that affects children. There are three types, all caused by a genetic change known as SMA1.
It tends to affect the trunk, legs, and arms. The long-term outlook depends on the type.The different types of MND share similar symptoms, but they progress at different speeds and vary in severity.
MND has three stages — early, middle, and advanced. Early stage signs and symptomsIn the early stage, symptoms develop slowly and can resemble those of other conditions. The symptoms will depend on the type of MND a person has and which part of the body it affects.Typical begin in one of the following areas:. the arms and legs. the mouth. the respiratory systemThey include:. a weakening grip, which makes it hard to pick up and hold things.
muscle pains, cramps, and twitches. slurred speech. weakness in the arms and legs. clumsiness and stumbling. difficulty swallowing. trouble breathing or shortness of breath.
inappropriate emotional responses, such as laughing or crying. weight loss, as muscles lose their massMiddle stage signs and symptoms. ALS can affect mobility, but assistive devices can enable a person to stay active.As the condition progresses, the early symptoms remain and become more severe.People may also experience:. muscle shrinkage. difficulty moving.
joint pain. drooling due to problems with swallowing. uncontrollable yawning, which can lead to jaw pain. changes in personality and emotional state. difficulty breathingStudies suggest that up to of people with ALS may experience brain involvement, including memory and language problems. Around 12–15% of people with ALS may develop.Some people also develop,.
Advanced stage signs and symptomsEventually, a person in the advanced stage of ALS will need help to move, eat, or breathe, and the condition can become life-threatening.Breathing problems are the cause of death. MNDs can occur in adults or children, depending on the type. They are more likely to affect men than women. Inherited forms of the condition may be present at birth. They are most likely to appear after the age of.The various types may have different risk factors. SMA is always hereditary, but this is not true for all forms of MND.According to NINDS, around of ALS cases in the United States are hereditary.
It is most likely to appear at the age of 55–75 years.They also note that veterans appear to have a 1.5–2 times higher chance of developing ALS than non-veterans. This may indicate that exposure to certain toxins increases the risk of having ALS.A 2012 found that footballers have a higher risk of dying from ALS, and other neurodegenerative diseases, compared with other people. Experts think that this could indicate a link with recurrent head trauma. There are different types of MND, and the outlook varies widely, depending on the type of condition.People with spinobulbar muscular atrophy, for example, can expect to have a. For other types, people may have a reduced life expectancy.New medications are emerging that may help slow the progression of MND. Are also investigating how to use to repair the damage that occurs with MND, in the hope of one day producing a cure.A better knowledge of genetic factors might also make it possible to prevent MND in those with inherited traits.
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'Death Moto 4' as a 'Death Moto 3' sequel, with new visual effects, more violent fighting experience.Ride your moto through the heavy enemies, reach the end.Multi-level crossing! Tornado rampage across rural roads, through the deep silence of the highway, or the rampage on the snowy street.No matter which way you chose to head-on, collision with killers is waiting for you. Unlock and upgrade 10 different motorcycles, each motor can be equipped with a variety of upgrade projects, such as nitrogen, machine guns, rocket launchers, and so on. Do not give any opportunity to killers! Intense chase, fierce fighting to survive. Upgrade the corresponding properties, increase the distance that you run in the game. Correctly use of nitrogen and dodge attacks from enemy to keep you fastest speed in a long time.
Control Moto to avoid violent tornado.
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